Publications by Silvia Cascianelli

Purpose: To provide reliable and reproducible heart/mediastinum (H/M) ratio cut-off values for parkinsonian disorders using two machine learning techniques, Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to [123I]MIBG cardiac scintigraphy. Procedures: We studied 85 subjects, 50 with idiopathic Parkinson’s disease, 26 with atypical Parkinsonian syndromes (P), and 9 with essential tremor (ET). All patients underwent planar early and delayed cardiac scintigraphy after [123I]MIBG (111 MBq) intravenous injection. Images were evaluated both qualitatively and quantitatively; the latter by the early and delayed H/M ratio obtained from regions of interest (ROIt1 and ROIt2) drawn on planar images. SVM and RF classifiers were finally used to obtain the correct cut-off value. Results: SVM and RF produced excellent classification performances: SVM classifier achieved perfect classification and RF also attained very good accuracy. The better cut-off for H/M value was 1.55 since it remains the same for both ROIt1 and ROIt2. This value allowed to correctly classify PD from P and ET: patients with H/M ratio less than 1.55 were classified as PD while those with values higher than 1.55 were considered as affected by parkinsonism and/or ET. No difference was found when early or late H/M ratio were considered separately thus suggesting that a single early evaluation could be sufficient to obtain the final diagnosis. Conclusions: Our results evidenced that the use of SVM and CT permitted to define the better cut-off value for H/M ratios both in early and in delayed phase thus underlining the role of [123I]MIBG cardiac scintigraphy and the effectiveness of H/M ratio in differentiating PD from other parkinsonism or ET. Moreover, early scans alone could be used for a reliable diagnosis since no difference was found between early and late. Definitely, a larger series of cases is needed to confirm this data.

Background/Aim: Proliferation biomarkers such as MIB-1 are strong predictors of clinical outcome and response to therapy in patients with non-small-cell lung cancer, but they require histological examination. In this work, we present a classification model to predict MIB-1 expression based on clinical parameters from positron emission tomography. Patients and Methods: We retrospectively evaluated 78 patients with histology-proven non-small-cell lung cancer (NSCLC) who underwent 18F-FDG-PET/CT for clinical examination. We stratified the population into a low and high proliferation group using MIB-1=25% as cut-off value. We built a predictive model based on binary classification trees to estimate the group label from the maximum standardized uptake value (SUVmax) and lesion diameter. Results: The proposed model showed ability to predict the correct proliferation group with overall accuracy >82% (78% and 86% for the low- and high-proliferation group, respectively). Conclusion: Our results indicate that radiotracer activity evaluated via SUVmax and lesion diameter are correlated with tumour proliferation index MIB-1.

Autonomous robotic platforms can be effectively used to perform automatic fruits yield estimation. To this aim, robots need data-driven models that process image streams and count, even approximately, the number of fruits in an orchard. However, training such models following a supervised paradigm is expensive and unpractical. Extending pre-trained models to perform yield estimation for a completely new type of fruit is even more challenging, but interesting since this situation is typical in practice. In this work, we combine a State-of-the-Art weakly-supervised fruit counting model with an unsupervised style transfer method for addressing the task above. In this sense, our proposed approach is quasi-unsupervised. In particular, we use a Cycle-Generative Adversarial Network (C-GAN) to perform unsupervised domain adaptation and train it alongside with a Presence-Absence Classifier (PAC) that discriminates images containing fruits or not. The PAC produces the weak-supervision signal for the counting network, that can then be used on the target orchard directly. Experiments on datasets collected in four different orchards show that the proposed approach is more accurate than the supervised baseline methods.

Wind turbine upgrades have recently been spreading in the wind energy industry for optimizing the efficiency of the wind kinetic energy conversion. These interventions have material and labor costs; therefore, it is fundamental to estimate the production improvement realistically. Furthermore, the retrofitting of the wind turbines sited in complex environments might exacerbate the stress conditions to which those are subjected and consequently might affect the residual life. In this work, a two-step upgrade on a multimegawatt wind turbine is considered from a wind farm sited in complex terrain. First, vortex generators and passive flow control devices have been installed. Second, the management of the revolutions per minute has been optimized. In this work, a general method is formulated for assessing the wind turbine power upgrades using operational data. The method is based on the study of the residuals between the measured power output and a judicious model of the power output itself, before and after the upgrade. Therefore, properly selecting the model is fundamental. For this reason, an automatic feature selection algorithm is adopted, based on the stepwise multivariate regression. This allows identifying the most meaningful input variables for a multivariate linear model whose target is the power of the upgraded wind turbine. For the test case of interest, the adopted upgrade is estimated to increase the annual energy production to 2.660.1%. The aerodynamic and control upgrades are estimated to be 1.8% and 0.8%, respectively, of the production improvement.